REMEDIES - Hypo Resetting Metabolic-memory in Endocrine Delta-cells In Episodic Severe Hypoglycaemia

Objetivo temático: Ciências Médicas e de Saúde

Área Científica: Biotecnologia Médica

Síntese do Projeto: Hypoglycaemia is a common cause of morbidity in patients treated with insulin, such as those with diabetes. It results from the failure of counter-regulatory mechanisms, particularly the impaired secretion of glucagon, the principal glucose-elevating hormone released by pancreatic α-cells. However, the mechanisms underlying the development of these defects remain unknown.

In this study, we will apply a comprehensive set of advanced techniques—including electrophysiology, live-cell imaging, biochemical assays, and transcriptomic analysis—to dissect a novel regulatory pathway of glucagon secretion and investigate how it becomes disrupted under pathological conditions.

Ultimately, our goal is to identify strategies to prevent recurrent hypoglycaemia and establish mechanistic foundations for the development of therapeutic interventions that could significantly improve diabetes management.

Área de intervenção: Biotecnologia Aplicada à Saúde

Investigador Responsável na UC: Quan Zhang

Unidade Orgânica UC: Universidade de Coimbra

Instituição Financiadora/Gestora: FCT - Fundação para a Ciência e a Tecnologia

Programa de Financiamento: MPr-2023-12 - SACCCT - IC&DT

Período de execução: 01/05/2025 a 29/04/2028

Custo total elegível (EUR): 232.416,00

Apoio financeiro da UE: 197.553,60

Apoio financeiro público nacional: 34.862,40

Técnico do Projeto: Sónia Branco (sonia.branco@uc.pt)

Contacto: +351 239 247 019