Vascular physiology group

Main achievements

1. Oxidative stress and inflammation are major players in vascular dysfunction

2. Perivascular adipose tissue dysfunction: a major role in type 2 diabetes with impact on vascular function

3. Several therapeutic approaches with beneficial properties reducing endothelial dysfunction associated with metabolic syndrome and diabetes

4. Adipokines are major players in vascular dysfunction with important therapeutic potential

Publications

Sena, C.M.; Pereira, A.; Seiça, R.M. Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2. Antioxidants 2023, 12, 82. doi.org/10.3390/antiox12010082

Sena CM, Gonçalves L, Seiça R. Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine. EPMA J. 2022 May 20;13(2):209-235. doi: 10.1007/s13167-022-00280-7

Sena CM, Seiça R, Perry G. Editorial: Oxidative Stress Revisited-Major Role in Vascular Diseases, Volume II. Front Physiol. 2022 Jan 12;12:826129. doi: 10.3389/fphys.2021.826129.

Sena, C.M. Perivascular adipose tissue: friend or foe? The Vasculome: From Many, One, 2022, pp. 71–75

Queiroz M, Leandro A, Azul L, Figueirinha A, Seiça R, Sena CM. Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats. Int J Mol Sci. 2021 Dec 20;22(24):13671. doi: 10.3390/ijms222413671.

Torrado-Salmerón C, Guarnizo-Herrero V, Henriques J, Seiça R, Sena CM, Torrado-Santiago S. Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats. Pharmaceutics. 2021 Mar 20;13(3):421. doi: 10.3390/pharmaceutics13030421.

Martins P, Pires A, Santos JL, Sena C, Seiça R. Atherosclerotic Process in Seroreverter Children and Adolescents Exposed to Fetal Antiretroviral Therapy. Curr HIV Res. 2021;19(3):216-224. doi: 10.2174/1570162X18999201118155026.

Leandro A, Queiroz M, Azul L, Seiça R, Sena CM. Omentin: A novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes. Free Radic Biol Med. 2021 Jan;162:233-242. doi: 10.1016/j.freeradbiomed.2020.10.021.

Queiroz M, Sena CM. Perivascular adipose tissue in age-related vascular disease. Ageing Res Rev. 2020 May;59:101040. doi: 10.1016/j.arr.2020.101040.

Martins P, Pires A, Albuquerque ME, Oliveira-Santos M, Santos J, Sena C, Seiça R. Myocardial peak systolic velocity-a tool for cardiac screening of HIV-exposed uninfected children. Eur J Pediatr. 2020 Mar;179(3):395-404. doi: 10.1007/s00431-019-03477-7.

Azul L, Leandro A, Boroumand P, Klip A, Seiça R, Sena CM. Increased inflammation, oxidative stress and a reduction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes. Free Radic Biol Med. 2020 Jan;146:264-274. doi: 10.1016/j.freeradbiomed.2019.11.002.

Sena CM, Seiça R, Perry G. Editorial: Oxidative Stress Revisited-Major Role in Vascular Diseases. Front Physiol. 2019 Jun 21;10:788. doi: 10.3389/fphys.2019.00788.

Sena CM. Epicardial adipose tissue: An important therapeutic target. Rev Port Cardiol. 2019 Jun;38(6):425-426. doi: 10.1016/j.repc.2019.07.001.

Martins P, Castela E, Rocha G, Sena C, Seiça R. Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach. Acta Med Port. 2017;30(10):742-749. doi: 10.20344/amp.8726.

Pereira A, Fernandes R, Crisóstomo J, Seiça RM, Sena CM. The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes. Sci Rep. 2017;7(1):14357. doi: 10.1038/s41598-017-14733-x.

Letra L, Sena C. Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction. Adv Neurobiol. 2017;19:163-189. doi: 10.1007/978-3-319-63260-5_7.

Sena CM, Pereira A, Fernandes R, Letra L, Seiça RM. Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: role of perivascular adipose tissue. Br J Pharmacol. 2017;174(20):3514-3526. doi: 10.1111/bph.13756.

Sena CM, Leandro A, Azul L, Seiça R, Perry G. Vascular Oxidative Stress: Impact and Therapeutic Approaches. Front Physiol. 2018;9:1668. doi: 10.3389/fphys.2018.01668.

Sena CM, Cipriano MA, Botelho MF, Seiça RM. Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation. Int J Mol Sci. 2018;19(9). pii: E2706. doi: 10.3390/ijms19092706.

Scientific interests and ongoing research projects

1. Vascular dysfunction in obesity and diabetes

2. Therapeutic approaches to tackle vascular dysfunction

3. Perivascular dysfunction in obesity and diabetes

Team

Group Leader

CS

Cristina Sena

PhD Members

CS

Cristina Sena

PhD Students

MQ

Marcelo Queiroz

FC

Fernanda Carrilho

MSc Students

MC

Mariana Castanheira

SC

Sandra Carreira

Autoriza o uso de cookies?