Inflammation Group

About

Inflammation is an important clinical and research topic, involving a complex set of interactions among soluble factors and cells that can arise in any tissue in response to an injury. This process normally leads to recovery and to healing, however, if targeted destruction and assisted repair are not properly phased, inflammation can lead to persistent tissue damage.

Biomarkers are functional, molecular/biochemical indicators of physiological or pathological processes. A crucial area of personalized medicine is to use biomarkers to provide vital information in determining disease prognosis, in predicting response to therapies, in establishing baseline risk and adverse events and drug interactions.

The mission of this group is to investigate cellular mechanisms of disease in order to establish novel biomarkers and conveying multiple inflammation induced pathologies during the whole human lifespan, unraveling pathways linked to each specific disease. As a multidisciplinary team, we fully intend to link our clinical understanding of disease and the interplay between disease and biomarkers.

Our group encompasses a wide range of expertise in medicine, cellular and molecular biology, cancer, reproductive science and immunology. We have established national and international collaborations with different research groups (University of Toronto; Instituto Português de Oncologia Porto; Nova Medical School, CINTESIS - Center for Health Technology and Services Research University of Porto Porto Portugal, Centre Hospitalier Universitaire Montpellier France)

Key targets of our group currently include aging, allergy, dentistry, obesity, diabetes, urological and brain cancers, pregnancy disorders, respiratory and renal diseases.

Publications

Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T. Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Apr;33(4):362-375. Epub 2022 Jan 19. doi: http://doi.org/10.1016/j.annonc.2022.01.002. IF: 32.976. Q1 - Category: Oncology

Sousa-Pinto B, Azevedo LF, Jutel M, Agache I, (…), Todo-Bom A, Bousquet J. Development and validation of combined symptom-medication scores for allergic rhinitis*. Allergy. 202277(7):2147-2162. Doi: https://doi.org/10.1111/all.15199. IF: 14.71. Q1 - Category: Allergy

Sousa-Pinto B, Sá-Sousa A, Vieira RJ, Amaral R, (…), Todo-Bom A, Bousquet J. Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air(R) real-world data. Allergy. 2022;77(9):2699-2711. Doi: https://doi.org/10.1111/all.15275. IF: 14.71. Q1 - Category: Allergy

Sousa-Pinto B, Schunemann H, Sa-Sousa A, Vieira RJ, (...), Todo-Bom A, Bousquet J. Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air (R) longitudinal study. Allergy. 2022 Nov. doi: https://doi.org/10.1111/all.15574. IF: 14.71. Q1 - Category. Allergy

Sousa-Pinto B, Schunemann H, Sa-Sousa A, Vieira RJ, (...), Todo-Bom A, Bousquet J. Comparison of rhinitis treatments using MASK-air (R) data and considering the minimal important difference. Allergy. 2022;77(10):3002-3014. doi: https://doi.org/10.1111/all.15371. IF: 14.71. Q1 - Category: Allergy

Zuberbier T, Dorr T, Aberer W, Montserrat A, (…), Todo-Bom A, Worm M. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA(2)LEN position paper. Allergy. 2022; 77(6):1736-1750. Doi: http://doi.org/10.1111/all.15167. IF: 14.71. Q1 - Category: Allergy

Bousquet J, Agache I, Blain H, Jutel M, Ventura MT, Worm M, Del Giacco S, Benetos A, Bilo BM, Czarlewski W, Abdul Latiff AH, Al-Ahmad M, (...), Todo-Bom A, et al. Management of anaphylaxis due to COVID-19 vaccines in the elderly. Allergy. 2021; 76(10):2952-2964. Doi: http://doi.org/10.1111/all.14838. IF: 13.146. Q1 - Category: Allergy; Q1 - Category: Immunology.

Bousquet J, Anto JM, Bachert C, Haahtela T, Zuberbier T, Czarlewski W, (…)Todo-Bom A, et al. Aria digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice. Allergy. 2021; 76(1): 1684-190. doi: http://doi.org/10.1111/all.14422. IF: 13.146. Q1 - Category: Allergy; Q1 - Category: Immunology.

Fankhauser CD, Oldenburg J, Albers P, Algaba F, Bokemeyer C, Boormans JL, Fischer S, Fizazi K, Gremmels H, Mayor de Castro J, Janisch F, Muilwijk T, Leão R, Nicol D, Nicolai N, Tandstad T, Pilar Laguna M. Recommendations to Balance Benefits and Risks of Thromboprophylaxis and to Avoid Central Venous-access Devices During First-line Chemotherapy in Men with Metastatic Germ Cell Tumors: The European Association of Urology Testicular Cancer Panel Position in 2021. Eur Urol. 2021 Jul;80(1):4-6. doi: http://doi.org/10.1016/j.eururo.2021.02.032. Epub 2021 Mar 12. PubMed PMID: 33722419. IF: 24.344. Q1 - Category: Urology & Nephrology.

Leão R, Albersen M, Looijenga LHJ, Tandstad T, Kollmannsberger C, Murray MJ, Culine S, Coleman N, Belge G, Hamilton RJ, Dieckmann KP. Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours: A Systematic Review. Eur Urol. 2021 Oct;80(4):456-466. doi: http://dx.doi.org/10.1016/j.eururo.2021.06.006. Epub 2021 Jun 24. Review. PubMed PMID: 34175151. IF: 24.2344 Q1 - Category: Urology & Nephrology.

Lee DD, Komosa M, Sudhaman S, Leão R, Zhang CH, Apolonio JD, Hermanns T, Wild PJ, Klocker H, Nassiri F, Zadeh G, Diplas BH, Yan H, Gallinger S, Pugh TJ, Ramaswamy V, Taylor MD, Castelo-Branco P, Nunes NM, Tabori U. Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer. J Clin Invest. 2021 Nov 1;131(21). doi: http://doi.org/10.1172/JCI146915. IF: 19.46. Q1 - Category: Medicine, Research & Experimental.

Nappi L, Thi M, Adra N, Hamilton RJ, Leão R, Lavoie JM, Soleimani M, Eigl BJ, Chi K, Gleave M, So A, Black PC, Bell R, Daneshmand S, Cary C, Masterson T, Einhorn L, Nichols C, Kollmannsberger C. Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors. Eur Urol. 2021 Jan;79(1):16-19. doi: http://doi.org/10.1016/j.eururo.2020.10.024. Epub 2020 Nov 4. PubMed PMID: 33158661. IF: 24.344. Q1 - Category: Urology & Nephrology

Alves I, Santos Pereira B, Dalebout H, Santos S, Vicente M, Campar A, Thepaut M, Fieschi F, Strahl S, Boyaval F, Vizcaino J, Roberto S, Holst-Bernarl S, Santos L, Wuhrer M, Marinho A, Heijs B, Pinho S. Protein mannosylation as a diagnostic and prognostic biomarker of lupus nephritis: an unusual glycan-neoepitope in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2021 april;73(11):2069-2077. Doi: http://doi.org/10.1002/ART.41768. IF: 15.483. Q1 – Category Rheumatology

Sousa-Pinto B, Filipe Azevedo L, Jutel M, Agache I, Canonica GW, (…)Todo-Bom A, et al. Development and validation of combined symptom-medication scores for allergic rhinitis. Allergy. 2021. doi: http://doi.org/10.1111/all.15199. IF: 13.146. Q1 - Category: Allergy; Q1 - Category: Immunology.

Zuberbier T, Dörr T, Aberer W, Alvaro M, Angier E, (…) Todo-Bom A, et al. Proposal of 0.5 mg of protein/100g of processed food as threshold for voluntary declaration of food allergen traces in processed food – A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA2LEN position paper. Allergy. 2021. doi: http://doi.org/10.1111/all.15167. IF: 13.146. Q1 - Category: Allergy; Q1 - Category: Immunology.

Nappi L, Thi M, Adra N, Hamilton RJ, Leão R, Lavoie JM, Soleimani M, Eigl BJ, Chi K, Gleave M, So A, Black PC, Bell R, Daneshmand S, Cary C, Masterson T, Einhorn L, Nichols C, Kollmannsberger C. Integrated Expression of Circulating miR375 and miR371 to Identify Teratoma and Active Germ Cell Malignancy Components in Malignant Germ Cell Tumors. European Urology. 2020 Nov 3;. doi: 10.1016/j.eururo.2020.10.024. PubMed PMID: 33158661. IF: 24.344. Q1 - Category: Urology & Nephrology

NCD Risk Factor Collaboration (NCD-RisC) (Mota-Pinto A). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020;396(10261):1511-1524. doi: http://doi.org/10.1016/S0140-6736(20)31859-6. IF: 60.39. Q1 - Category: General & Internal Medicine

Bédard A, Basagaña X, Anto JM, Garcia-Aymerich J, Devillier P, (…), Todo-Bom A, et al; MASK study group. Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study. J Allergy Clin Immunol. 2019 Jul;144(1):135-143.e6. http://dx.doi.org/10.1016/j.jaci.2019.01.053. IF: 14.11 Q1 - Categoria: Alergia; Q1 - Category: Immunology.

Bousquet J, Hellings PW, Agache I, Amat F, Annesi-Maesano I, (…), Mota-Pinto A, Todo-Bom A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Allergy Clin Immunol. 2019;143(3):864-879 J Allergy Clin Immunol. 2019 Mar;143(3):864-879. Erratum in: J Allergy Clin Immunol. 2019 Nov;144(5):1456. http://doi.org/10.1016/j.jaci.2018.08.049. IF: 14.11. Q1 - Category: Immunology and Allergy

Nappi L, Thi M, Lum A, Huntsman D, Eigl BJ, Martin C, O'Neil B, Maughan BL, Chi K, So A, Black PC, Gleave M, Wyatt AW, Lavoie JM, Khalaf D, Bell R, Daneshmand S, Hamilton RJ, Leão RRN, Nichols C, Kollmannsberger C. Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum. J Clin Oncol. 2019 Sep 25; JCO1802057. http://dx.doi.org/10.1200/JCO.18.02057. PubMed PMID: 31553692. IF:44.544. Q1 - Category: Oncology.

NCD Risk Factor Collaboration (NCD-RisC), Mota-Pinto A. Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature 2019;569(7755):260-264. doi: http://dx.doi.org/10.1038/s41586-019-1171-x. IF: 43.07. Q1 - Category: Multidisciplinary Sciences

Scientific interests and ongoing research projects

We have 26 ongoing projects, from which selected the following:

1. Cons©elhos Repórteres 55+ BPI “la Caixa” Rural. Referência do projeto: CR55+. Parceiros: Caritas Diocesana de Coimbra, Portugal; Universidade de Coimbra Faculdade de Medicina, Portugal; Universidade de Coimbra Faculdade de Letras, Portugal; Universidade de Coimbra Faculdade de Psicologia e de Ciências da Educação, Portugal. Investigadores: Anabela Mota-Pinto. Financiador: BPI Lisboa. Data de início: 2019. Financiamento – 48.406,00€

2. Otimização de métodos para deteção por espectrometria de massa de biomarcadores de resposta imunitária em cancros urológicos. CEDOC, Nova Medical School, FMUC. Investigador Co-Principal: Leão R. Funding: FCT Research Grant PTDC/BTM-TEC/1746/2021. 249.033,83 €. 2021.

3. miR-371a-3p assessment in liquid biopsies improve clinical decision for testicular lesions. FMUC, ICBAS. Investigador Principal: Leão R. Funding: Associação Apoio Centro Investigação em Meio Ambiente, Genética e Oncobiologia. 2020. 5000 €.

4. Unravelling the potential of extracellular vesicles as biomarkers of Intraductal and Cribriform Prostate Cancer. FMUC, CEDOC. Co-Investigator: Leão R. Funding by Janssen: 1.000.029 €. 2020.

5. Environmental monitoring of SARS-CoV-2 in an hemodialysis unit: a quest for preventing transmission in healthcare facilities. Helena Sá, Co-investigadora. Projeto no âmbito da pandemia COVID-19 submetido em 15/5/2020 à Fundação Ciência Tecnologia intitulado Investigador principal: Dr. Gil Roberto Correia Lopes, Faculdade de Medicina de Coimbra, com aprovação em 8 de junho de 2020 (projeto nº679, financiamento de 40 000 Euros.

Team

Group Leader

Anabela Mota Pinto

apinto@uc.pt

Researchgate DeGóis

PhD Members

Anabela Mota Pinto

apinto@uc.pt

Researchgate DeGóis

AM

Ana Areia, MD

AM

Ana Todo Bom, MD

HM

Helena Oliveira Sá, MD

JM

José Luís Alves, MD

LM

Lèlita Santos, MD

RM

Ricardo Leão, MD

PhD Students

JA

Jani Almeida

Other members

SM

Sofia do Vale Pereira, MD

VA

Vera Alves

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