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Main achievements
Publications
Scientific interests and ongoing research projects
Team

Cell Signalling, Epidemiology, Clinic and Cancer Therapy Group

Main achievements

1. Identification of diagnostic/prognostic and drug response biomarkers are group contributions: oxidative stress and DNA methylation are complementary prognostic biomarkers in myelodysplastic syndromes (MDS) patients; plasmatic peroxides levels are good predictive biomarkers of response to erythropoiesis-stimulating agents in lower-risk MDS; drug transporters variants as good susceptibility and prognostic biomarkers in chronic myeloid leukemia (CML) and the hydropathy index of the HCDR3 sequences of chronic lymphocytic leukemia (CLL) cells allows the identification of a subgroup of CLL patients with intermediate prognostic features. Moreover, Blood-based specimens may be potential source of non-invasive DNA methylation cancer biomarkers in MDS.

2. The assessment of different immune cells’ status in neoplasias context revealed the impact of an immunosuppressive state on patients’ stratifications, prognosis, and therapy monitoring.

3. Evaluation of therapeutic potential of new compounds in different neoplasias to improve or overcome lack of response of current approaches

4. In the context of international networking, reviews in high-impact journals were published focused on therapy resistance, the impact of metabolism and hypoxia in cancer, the role of immune system in cancer prognosis and monitoring, the molecular mechanisms of tyrosine kinase inhibitors resistance in CML and the elaboration of international (European) guidelines/consensus on cancer (mainly dermatological) and skink allergic diseases.

Publications

Costa MI, Sarmento-Ribeiro AB, Gonçalves AC. Zinc: From Biological Functions to Therapeutic Potential. Int J Mol Sci. 2023. 24(5):4822. doi: 10.3390/ijms24054822. IF: 6.208. Q1 Categoria: Biochemistry & Molecular Biology, Q2 Categoria: Chemistry, Multidisciplinary

Ribeiro H, Alves R, Jorge J, Gonçalves AC, Sarmento-Ribeiro AB, Teixeira-Veríssimo M, Dourado M, Andrade JP. Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe Dementia. Biomedicines. 2023.11(2):380. doi: 10.3390/biomedicines11020380. IF: 4.757. Q2 Categoria Medicine, Research & Experimental; Q2 Categoria Biochemistry & Molecular Biology

Alves R, Santos D, Jorge J, Gonçalves AC, Catarino S, Girão H, Melo JB, Sarmento-Ribeiro AB. Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines. Molecules. 2023. 28(3):1210. doi: 10.3390/molecules28031210. IF: 4.927. Q2 Categoria: Biochemistry & Molecular Biology, Q2 Categoria: Chemistry, Multidisciplinary

Marques MP, Neves BG, Varela C, Zuzarte M, Gonçalves AC, Dias MI, Amaral JS, Barros L, Magalhães M, Cabral C. Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiproliferative Effect on Glioblastoma Cells. Pharmaceutics. 2023 Jan 19;15(2):341. doi: 10.3390/pharmaceutics15020341. IF: 6.525. Q1. Category: Pharmacology & pharmacy

Almeida SF, Fonseca A, Sereno J, Ferreira H, Lapo-Pais M, Martins-Marques T, Rodrigues T, Oliveira RC, Miranda C, Almeida LP, Girão H, Falcão A, Abrunhosa AJ, Gomes CM. Osteosarcoma-derived exosomes as potential PET imaging nanocarriers for lung metastasis. Small 2022, 18(49): 2203999. doi: 10.1002/smll.202203999. IF: 15.153, Q1 Categoria: Chemistry, Multidisciplinarity

Alves F, Calado R, Relvas M, Gomes T, Gonçalo M. Short courses of ciclosporin can induce long remissions in chronic spontaneous urticaria. J Eur Acad Dermatol Venereol. 2022 Aug;36(8):e645-e646. doi: 10.1111/jdv.18107. IF: 9.228. Q1 Categoria: Dermatology

Alves R, Gonçalves AC, Jorge J, Marques G, Ribeiro AB, Tenreiro R, Coucelo M, Diamond J, Oliveiros B, Pereira A, Freitas-Tavares P, Almeida AM, Sarmento-Ribeiro AB. Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis. Int J Mol Sci. 2022 Aug 29;23(17):9815. doi: 10.3390/ijms23179815. IF: 6.208. Q1 Categoria: Biochemistry & Molecular Biology, Q2 Categoria: Chemistry, Multidisciplinary

Calvão J, Figueiredo C, Gonçalo M. Patch testing in fixed drug eruptions: a 12-year retrospective study. J Eur Acad Dermatol Venereol. 2022 Oct;36(10):e770-e772. doi: 10.1111/jdv.18290. Epub 2022 Jun 13. IF: 9.228. Q1 Categoria: Dermatology

Costa MI, Lapa BS, Jorge J, Alves R, Carreira IM, Sarmento-Ribeiro AB, Gonçalves AC. Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells. Int. J. Mol. Sci. 2022, 23, 2567. doi: 10.3390/ijms23052567 IF: 6.208. Q1 Categoria: Biochemistry & Molecular Biology, Q2 Categoria: Chemistry, Multidisciplinary

Domingues C, Santos A, Alvarez-Lorenzo C, Concheiro A, Jarak I, Veiga F, Barbosa I, Dourado M, Figueiras A. Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology. ACS Nano. 2022;16: 9994-10041. doi: 10.1021/acsnano.2c00128. IF: 18.027. Q1 Categoria: Chemistry, Multidisciplinary; Q1 Categoria: Chemistry, Physical

Gauci ML, Aristei C, Becker JC, Blom A, Bataille V, Dreno B, Del Marmol V, Forsea AM, Fargnoli MC, Grob JJ, Gomes F, Hauschild A, Hoeller C, Harwood C, Kelleners-Smeets N, Kaufmann R, Lallas A, Malvehy J, Moreno-Ramirez D, Peris K, Pellacani G, Saiag P, Stratigos AJ, Vieira R, Zalaudek I, van Akkooi ACJ, Lorigan P, Garbe C, Lebbé C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC). Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022. Eur J Cancer. 2022. 171:203-231. doi: 10.1016/j.ejca.2022.03.043. IF: 10.002. Q1. Category: Oncology

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC). European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022. Eur J Cancer. 2022. 170:236-255. doi: 10.1016/j.ejca.2022.03.008. IF: 10.002. Q1. Category: Oncology

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC). European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022. Eur J Cancer. 2022. 170:256-284. doi: 10.1016/j.ejca.2022.04.018. IF: 10.002. Q1. Category: Oncology

Laranjeira P, Pedrosa M, Duarte C, Pedreiro S, Antunes B, Ribeiro T, Dos Santos F, Martinho A, Fardilha M, Domingues MR, Abecasis M, Pereira da Silva JA, Paiva A. Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory Response of Monocytes and Myeloid Dendritic Cells from Patients with Rheumatoid Arthritis. Pharmaceutics. 2022 Feb 12;14(2):404. doi: 10.3390/pharmaceutics14020404. IF: 6.525. Q1: Categoria: Pharmacology & Pharmacy

Neves FL, Amaral MNGA, Silva SFDD, Silva IMM, Laranjeira PMDS, Pinto CRJ, Paiva AA, Dias ASDS, Coelho MLACV. Immunoparalysis in critically ill children. Immunology 2022. doi: 10.1111/imm.13595. Epub ahead of print. IF: 7.215. Q2 Categoria: Immunology

Rodriguez S, Celay J, Goicoechea I, Jimenez C, Botta C, Garcia-Barchino MJ, Garces JJ, Larrayoz M, Santos S, Alignani D, Vilas-Zornoza A, Perez C, Garate S, Sarvide S, Lopez A, Reinhardt HC, Carrasco YR, Sanchez-Garcia I, Larrayoz MJ, Calasanz MJ, Panizo C, Prosper F, Lamo-Espinosa JM, Motta M, Tucci A, Sacco A, Gentile M, Duarte S, Vitoria H, Geraldes C, Paiva A, Puig N, Garcia-Sanz R, Roccaro AM, Fuerte G, San Miguel JF, Martinez-Climent JA, Paiva B. Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma. Sci Adv. 2022 Jan 21;8(3):eabl4644. doi: 10.1126/sciadv.abl4644. Epub 2022 Jan 19. IF: 14.980. Q1: Categoria: Multidisciplinary Sciences

Alves R, Gonçalves AC, Rutella S, Almeida AM, De Las Rivas J, Trougakos IP, Sarmento Ribeiro AB. Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia-From Molecular Mechanisms to Clinical Relevance. Cancers. 2021. 13(19):4820. doi.org/10.3390/cancers13194820. IF: 6.639. Q1 Categoria: Oncology; Q2 Categoria: Cancer Research

Bizjak M, Košnik M, Dinevski D, Thomsen SF, Fomina D, Borzova E, Kulthanan K, Meshkova R, Ahsan DM, Al-Ahmad M, Altrichter S, Bauer A, Brockstädt M, Costa C, Demir S, Criado RF, Ensina LF, Gelincik A, Giménez-Arnau AM, Gonçalo M, Gotua M, Holm JG, Inomata N, Kasperska-Zajac A, Khoshkhui M, Klyucharova A, Kocatürk E, Lu R, Makris M, Maltseva N, Miljković J, Pasali M, Paulino M, Pesqué D, Peter J, Dario Ramón G, Ritchie C, Valle SOR, Rudenko M, Sikora A, de Souza Lima EM, Wagner N, Xepapadaki P, Xue X, Zhao Z, Terhorst-Molawi D, Maurer M. Risk factors for systemic reactions in typical cold urticaria: results from the COLD-CE study. Allergy. 2021. doi: 10.1111/all.15194. IF: 13.146. Q1 Categoria: Immunology; Immunology and Allergy

Gonçalves AC, Alves R, Baldeiras I, Jorge J, Marques B, Paiva A, Oliveiros B, Cortesão E, Nascimento Costa JM, Sarmento-Ribeiro AB. Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients. Front Cell Dev Biol. 2021. 9:701328. doi: 10.3389/fcell.2021.701328. IF: 6.684. Q1 Categoria: Cell biology; Developmental biology

Gonçalves AC, Richiardone E, Jorge J, Polónia B, Xavier CPR, Salaroglio IC, Riganti C, Vasconcelos MH, Corbet C, Sarmento-Ribeiro AB. Impact of cancer metabolism on therapy resistance - Clinical implications. Drug Resist Updat. 2021. 100797. doi.org/10.1016/j.drup.2021.100797. IF: 18.500. Q1 Categoria: Cancer research; Infectious diseases; Oncology; Pharmacology; Pharmacology (medical)

Kopecka J, Salaroglio IC, Perez-Ruiz E, Sarmento-Ribeiro AB, Saponara S, De Las Rivas J, Riganti C. Hypoxia as a driver of resistance to immunotherapy. Drug Resist Updat. 2021. 100787. doi: 10.1016/j.drup.2021.100787. IF: 18.500. Q1 Categoria: Cancer research; Infectious diseases; Oncology; Pharmacology; Pharmacology (medical)

Longhurst HJ, Gonçalo M, Godse K, Ensina LF. 18. Managing Chronic Urticaria and Recurrent Angioedema Differently with Advancing Age. J Allergy Clin Immunol Pract. 2021. 9(6): 2186-2194. doi: 10.1016/j.jaip.2021.03.034. IF: 8.861. Q1 Categoria: Immunology and Allergy

Balato A, Ayala F, Bruze M, Crepy MN, Gonçalo M, Johansen J, John SM, Pigatto P, Raimondo A, Rustemeyer T, Schuttelaar MA, Svedman C, Aerts O, Uter W, Wilkinson M, Gimenez-Arnau A. European Task Force on Contact Dermatitis statement on coronavirus disease-19 (COVID-19) outbreak and the risk of adverse cutaneous reactions. J Eur Acad Dermatol Venereol. 2020, 34(8):e353-e354. doi: 10.1111/jdv.16557. IF: 5.248. Q1 Categoria: Dermatology, Q1 Categoria: Infectious Diseases

Pérez-Ruiz E, Melero I, Kopecka J, Sarmento-Ribeiro AB, García-Aranda M, De Las Rivas J. Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies. Drug Resist Updat. 2020. 53:100718. doi: 10.1016/j.drup.2020.100718. IF: 11.00. Q1 Categoria: Cancer Research, Q1 Categoria: Infectious Diseases, Q1 Categoria: Oncology, Q1 Categoria: Pharmacology, Q1 Categoria: Pharmacology (medical)

Assaraf YG, Brozovic A, Gonçalves AC, Jurkovicova D, Linē A, Machuqueiro M, Saponara S, Sarmento-Ribeiro AB, Xavier CPR, Vasconcelos MH. The multi-factorial nature of clinical multidrug resistance in cancer. Drug Resist Updat. 2019 Sep; 46:100645. doi: 10.1016/j.drup.2019.100645. IF: 11.708. Q1 Categoria: Oncology

Martín-Sierra C, Laranjeira P, Domingues MR, Paiva A. Lipoxidation and cancer immunity. Redox Biol. May; 23:101103. doi: 10.1016/j.redox.2019.101103. Review. IF: 7.793. Q1 Categoria: Biochemistry

Sarmento-Ribeiro AB, Scorilas A, Gonçalves AC, Efferth T, Trougakos IP. The emergence of drug resistance to targeted cancer therapies: Clinical evidence. Drug Resist Updat. 2019 Dec; 47:100646. doi: 10.1016/j.drup.2019.100646. IF: 11.708. Q1 Categoria: Oncology

Scientific interests and ongoing research projects

1. canSERV (Providing cutting edge cancer research services across Europe). IR: EATRIS. Particiapnts: Laranjeira P, Paiva A. Funding: European Comission HORIZON-INFRA-2021-SERV-01. 2021.

2. Clinical relevance of platelets as non-invasive biomarkers in diffuse large B-cell lymphoma – A pilot study. Coordinator: Sarmento Ribeiro AB. Participants: Gonçalves AC, Lapa B, Jorge J, Alves R, Geraldes C, Cortesão E, Carda JP. Funding: LPCC-NRC/CIMAGO, SPH 2021-2023.

CuidIn - Apoiar e Cuidar do Cuidador Informal (N/Ref.ª: 3695/POISE/EMPIS/SI/3.33/2020). Coordinators: Dourado M and Ferreira P. Funding: Portugal 2020/ POISE-03-4639-EU-FSE-000765. 2020-2023.

3. Eventos adversos imunológicos dos inibidores dos “check-point” imunológicos – estudo dos seus fenótipos e biomarcadores. Coordinator: Gonçalo M. Funding: FMUC- PEPITA. 2019-2022.

4. New diagnostic and therapeutic tools against multidrug resistant tumors - COST action CA17104. PI: Chiara Riganti (U Turin, Italy). Participant: Sarmento Ribeiro AB, Gonçalves AC, Alves R. Funding: European Comission-COST. 2018-2022.

5. Radiolabeled EXosomes - a nanotheranostic tool for lung micrometastasis in osteosarcoma. (PTDC/BTM-SAL/4451/2020). Coordinator: Gomes C. Funding: FCT. 2021-2023.

6. Red Transfronteriza de Innovación en Diagnóstico Precoz de Leucemia para un envejecimiento saludable – IDIAL-NET. Coordinators: Orfão A. and Sarmento Ribeiro AB. Funding: Interreg-POCTEP 2019-2022

Team

Group Leader

Ana Bela Sarmento Ribeiro

PhD Members

Adélia Simão, MD

Ana Bela Sarmento Ribeiro, MD

Ana Cristina Gonçalves

António Bernardes, MD

Artur Paiva

Belmiro Parada, MD

Catarina Geraldes, MD

Célia Gomes

Emília Cortesão, MD

José Casanova, MD

Luís Semedo, MD

Margarida Gonçalo, MD

Maria Manuel Donato

Marília Dourado, MD

Paulo Donato, MD

Paula Laranjeira

Raquel Alves

Ricardo Vieira, MD

Sara Duarte, MD

Vitor Rodrigues, MD

Vitor Sousa, MD

PhD Students

Ana Isabel Sebastião

André Lazaro, MD

Bárbara Marques, MD

Beatriz Lapa

Carla Diogo, MD

Catarina Melo, MD

Catarina Quintas, MD

Cátia Domingues

Diana Rodrigues

Diogo Moura, MD

Edgar Pratas, MD

Catarina Melo, MDFrederico Furriel, MD

Gabriela Ribeiro

Hugo Ribeiro, MD

Inês Costa

Inês Gois, MD

Isabel Ferreira, MD

Ivanna Hrynchak

Joana Azevedo, MD

Joana Jorge

João Paulo Freitas, MD

João Pedro Oliveira, MD

Liliana Santos

Margarida Coucelo

Mário Lourenço, MD

Marta Pereira, MD

Rita Canário, MD

Ruben Fonseca, MD

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