Programme

RESETageing Conference: Biology of Ageing: Senescence and Cell Stress

Newcastle University

Newcastle upon Tyne, UK

Programme

(United Kingdom local time)

16 September

11:00-14:00 Registration opening

14:00-14:15 Welcome and introduction

Joris Veltman, Dean of Biosciences Institute, Newcastle University

Lino Ferreira, coordinator of RESETageing project, University of Coimbra

Session 1: Ageing: from model systems to humans

Chair: Gavin Richardson

14:15 - 14:55 Keynote Lecture: Adam Antebi (University of Cologne) A TFEB/TGF-β axis regulates stem cell quiescence, activation, and rejuvenation in the adult reproductive diapause

14:55 - 15:10 James T. Murray - Using African Turquoise Killifish as a model for investigating proteostasis regulation during ageing

15:10 - 15:20 Peter Clark - Hypothetical use of cyclic Yamanaka factor expression as a human rejuvenation therapy

15:20 - 15:30 Francesca Tomatis - Engineering extracellular vesicles with microRNAs to cross the blood-brain barrier

15:30 - 15:40 Beatriz Martins - Role of extracellular vesicles secretion induced by inflammation on retinal pigment epithelial cells dysfunction in age-related macular degeneration

15:40 - 16:05 Invited Speaker: Miles Witham (Newcastle University) Building the capacity to translate discoveries in ageing biology and epidemiology to intervention studies in humans across the life course - Introducing the ART of Healthy Ageing Network

Coffee break

Session 2: Biology of Ageing

Chair: Daryl Shanley

16:30 - 17:10 Keynote Lecture: Dudley Lamming (University of Wisconsin) When a calorie is not just a calorie: The regulation of health and longevity by what and when we eat

17:10 - 17:25 Lynne S Cox - mTOR inhibition resets multiple hallmarks of ageing

17:25 - 17:35 Mario D. Cordero - Blockade of the NLRP3 inflammasome improves mental health and lifespan in obese mice

17:35 - 17:45 Joana Silva - MicroRNA-199b is involved in both LV and RV pathological remodeling through distinct molecular mechanisms

17:45 - 18:10 Invited Speaker: Henrique Girão (University of Coimbra) Communication derailment in cardiovascular diseases

18:10 - 20:00 Poster Session, Wine and cheese

20:00 Gala Dinner: St. James’ Park, Newcastle United Football Stadium

17 September

Session 3: Mechanisms of Ageing

Chair: Daryl Shanley

09:30 - 10:15 Keynote Lecture: Vera Gorbunova (University of Rochester) Mechanisms of longevity: from long-lived mammals to human centenarians

10:15 - 10:40 Invited Speaker: Alberto Sanz (University of Glasgow) Mitochondria regulate lifespan through a developmental “window of opportunity”

10:40 - 10:50 Beatriz Castejón Vega - Mitochondrial Complex IV activity during development determine lifespan

Coffee break

Session 4: Senescence and Ageing

Chair: Alessandro Ori

11:30 - 11:55 Invited Speaker: Masashi Narita (Cancer Research UK Cambridge Institute) Senescence Lifecycle in cancer and ageing

11:55 - 12:10 Gavin D Richardson - Cardiomyocyte-specific inhibition of p16ink4 improves recovery following myocardial infarction with reperfusion

12:10 - 12:20 Simão Correia-Santos - ABT263 – alleviating the Hutchinson Gilford Progeria Syndrome (HGPS) senescent phenotype

12:20 - 12:30 Patrícia R. Pitrez - Extracellular matrix as a trigger for cellular senescence

12:30 - 12:55 Invited Speaker: Satomi Miwa (Newcastle University) Senescent cell mitochondrial function as a target for anti-senescence therapies

Lunch

Session 5: Molecular turnover in Ageing

Chair: Alberto Sanz

14:15 - 14:55 Keynote Lecture: David Vilchez (University of Cologne) - Proteostasis of Aging and Stem Cells

14:55 - 15:10 Susana Rosa - The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program

15:10 - 15:20 Nisha Hemandhar Kumar - Measuring and interpreting protein turnover and mRNA level changes in the aging brain

15:20 - 15:30 Domenico Di Fraia - Multi-modal proteome analysis of Nothobranchius furzeri brain aging highlight proteostasys alteration of specific mitochondrial proteins

15:30 - 15:55 Invited speaker: Ira Milosevich (University of Coimbra) Towards improving synaptic transmission in the ageing mammalian brain

Coffee break

Session 6: Age-related disease and anti-ageing interventions

Chair: Satomi Miwa

16:30 - 16:55 Invited Speaker: Cristina Rego (University of Coimbra) Mitochondrial-related age markers in models of Alzheimer’s diseases– role of histone deacetylase inhibitors

16:55 - 17:05 Edward Fielder - Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

17:05 - 17:30 Invited Speaker: Paula Costa Martins (Maastricht University) - Targeting RNA to facilitate cardiac remodeling and to treat heart failure

17:30 - 17:40 Jordy MM Kocken - Vesper, a novel lncRNA is necessary for the right ventricle in response to pressure overload

17:40 - 18:00 Conference closing, Poster awards

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